Binomial Mixture Model-based Association Tests under Genetic Heterogeneity
نویسندگان
چکیده
منابع مشابه
Binomial mixture model-based association tests under genetic heterogeneity.
Most of the existing association tests for population-based case-control studies are based on comparing the mean genotype scores between the case and control groups, which may not be efficient under genetic heterogeneity. Given that most common diseases are genetically heterogeneous, caused by mutations in multiple loci, it may be beneficial to fully account for genetic heterogeneity in an asso...
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ژورنال
عنوان ژورنال: Annals of Human Genetics
سال: 2009
ISSN: 0003-4800,1469-1809
DOI: 10.1111/j.1469-1809.2009.00542.x